# Dementia in Schizophrenia Reflects Intrinsic Disease Not Neurodegeneration **URL:** \ **Category:** News on schizophrenia and mental health matters\ **Created:** [May 13, 2026, 6:35pm UTC](https://schizophreniasupport.discourse.group/t/dementia-in-schizophrenia-reflects-intrinsic-disease-not-neurodegeneration/5350 "2026-05-13T18:35:51Z")\ **Posts on this page:** 2\ **Page:** 1
**Author:** ![firemonkey](https://yyz2.discourse-cdn.com/flex012/user_avatar/schizophreniasupport.discourse.group/firemonkey/32/1229_2.png) [@firemonkey](https://schizophreniasupport.discourse.group/u/firemonkey)\ **Post date:** [May 13, 2026, 6:35pm UTC](https://schizophreniasupport.discourse.group/t/dementia-in-schizophrenia-reflects-intrinsic-disease-not-neurodegeneration/5350/1 "2026-05-13T18:35:51Z")
Dementia in severe, extremely treatment-resistant schizophrenia is a distinct cognitive syndrome that is not adequately explained by Alzheimer disease (AD), other neurodegenerative dementias, antipsychotic exposure, cardiometabolic risk factors, poor effort, premorbid intellectual disability, or long-term institutionalization. These study results were published in _JAMA Psychiatry_. Researchers conducted a retrospective cohort study to characterize clinical, cognitive, and genetic features of dementia in individuals with severe, extremely treatment-resistant schizophrenia. [https://www.psychiatryadvisor.com/news/dementia-in-schizophrenia-reflects-intrinsic-disease-not-neurodegeneration/](https://www.psychiatryadvisor.com/news/dementia-in-schizophrenia-reflects-intrinsic-disease-not-neurodegeneration/) ---
**Author:** ![sweetpotatopie](https://yyz2.discourse-cdn.com/flex012/user_avatar/schizophreniasupport.discourse.group/sweetpotatopie/32/8234_2.png) [@sweetpotatopie](https://schizophreniasupport.discourse.group/u/sweetpotatopie)\ **Post date:** [June 21, 2026, 3:12pm UTC](https://schizophreniasupport.discourse.group/t/dementia-in-schizophrenia-reflects-intrinsic-disease-not-neurodegeneration/5350/2 "2026-06-21T15:12:14Z")