# Why a Promising Schizophrenia Drug May Never Work for Some Patients

**URL:** <https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580>\
**Category:** News on schizophrenia and mental health matters\
**Created:** [January 12, 2026, 5:24pm UTC](https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580 "2026-01-12T17:24:23Z")\
**Posts on this page:** 6\
**Page:** 1

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**Author:** ![everhopeful](https://yyz2.discourse-cdn.com/flex012/user_avatar/schizophreniasupport.discourse.group/everhopeful/32/605_2.png) [@everhopeful](https://schizophreniasupport.discourse.group/u/everhopeful)\
**Post date:** [January 12, 2026, 5:24pm UTC](https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580/1 "2026-01-12T17:24:23Z")

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> **[Why a Promising Schizophrenia Drug May Never Work for Some Patients](https://www.technologynetworks.com/tn/news/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients-408485)**
>
> Researchers studied a TAAR1 variant found in an Indian family with schizophrenia and showed that a single amino acid change collapses the receptor’s structure. The mutation blocks drug binding, reduces receptor trafficking, and eliminates signaling.

> Pharmaceutical companies have invested heavily in drugs, such as ulotaront, that target this receptor. However, recent clinical trials for ulotaront did not meet expectations, leaving researchers asking if genetic differences between patients are to blame.

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**Author:** ![LivingWith](https://avatars.discourse-cdn.com/v4/letter/l/22d042/32.png) [@LivingWith](https://schizophreniasupport.discourse.group/u/LivingWith)\
**Post date:** [January 12, 2026, 5:29pm UTC](https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580/2 "2026-01-12T17:29:35Z")

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Thanks for posting @everhopeful

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**Author:** ![labratmat](https://yyz2.discourse-cdn.com/flex012/user_avatar/schizophreniasupport.discourse.group/labratmat/32/16_2.png) [@labratmat](https://schizophreniasupport.discourse.group/u/labratmat)\
**Post date:** [January 12, 2026, 5:36pm UTC](https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580/3 "2026-01-12T17:36:01Z")

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Thus not being South Asian Ulotaront may work for me…

APs in general work for one and not another in the field.

I’d like a genetic screening to see which ones work for me and which do not, is this avaialble yet?

Copilot says this test isn’t available yet. No dosing considerstions can be made from a genetic test for cobenfy or ulotaront at present with the current genomic tests privately or nhs wise.

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**Author:** ![labratmat](https://yyz2.discourse-cdn.com/flex012/user_avatar/schizophreniasupport.discourse.group/labratmat/32/16_2.png) [@labratmat](https://schizophreniasupport.discourse.group/u/labratmat)\
**Post date:** [January 12, 2026, 5:45pm UTC](https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580/4 "2026-01-12T17:45:04Z")

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Chatting with copilot it says that this genetic marker is rare and wouldn’t have been the deciding factor in phase 3 fda failure.

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**Author:** ![everhopeful](https://yyz2.discourse-cdn.com/flex012/user_avatar/schizophreniasupport.discourse.group/everhopeful/32/605_2.png) [@everhopeful](https://schizophreniasupport.discourse.group/u/everhopeful)\
**Post date:** [January 12, 2026, 5:46pm UTC](https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580/5 "2026-01-12T17:46:40Z")

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Interesting. Thanks.

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**Author:** ![SzSupportAdmin](https://yyz2.discourse-cdn.com/flex012/user_avatar/schizophreniasupport.discourse.group/szsupportadmin/32/334_2.png) [@SzSupportAdmin](https://schizophreniasupport.discourse.group/u/SzSupportAdmin)\
**Post date:** [January 25, 2026, 6:00am UTC](https://schizophreniasupport.discourse.group/t/why-a-promising-schizophrenia-drug-may-never-work-for-some-patients/1580/6 "2026-01-25T06:00:08Z")

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